#endothelial function

2 articles

Approach: human outcome. Palette: natural.

Close, low-angle shot of an older adult's bare lower leg and bare feet resting on crisp white hospital bed linen, with a soft, out-of-focus window in the background. The camera sits at mattress level and looks along the calf toward the ankle. Face is not visible. A small ultrasound probe coated in clear gel presses against the back of the knee. The operator's gloved hand enters from the frame edge. Soft overcast daylight from the window gives skin tones a warm, realistic look. Around the bed, a sprig of fresh rosemary and a few purple-green ashwagandha leaves sit on a wooden bedside tray. The leaves provide plant-green accents, along with one small electric green sensor light on a monitor. Palette: natural greens, wood browns and warm skin. Mood: quiet, careful and hopeful.

PB125：卧床期间维持动脉功能的植物性 Nrf2 混合物

BY NOVA CHEN · 2026年10月31日

PB125 是一种由迷迭香、印度人参（ashwagandha）和黄酮类化合物 luteolin 组成的植物性 Nrf2 激活剂。近期一项小规模、双盲的人体试验在 44 名受试者中检验了其效果。24 名老年受试者每日服用 200 mg，连续两周后，上臂血流介导扩张（FMD）从 2.8% 提升至 3.8%，膝后血管 FMD 从 1.5% 提升至 2.3%。在随后五天的卧床期间，PB125 组的动脉功能和抗氧化水平保持稳定，而安慰剂组出现下降。年轻受试者虽然基线 FMD 未提升，但在肢体固定期间仍表现出对膝后 FMD 的保护。由于样本量小且仅使用替代终点，这一发现更像是积极信号，而非临床疗效的确凿证明。

**Approach:** Conceptual metaphor, in a bold color field palette (D).

A single ripe pomegranate, split open, on a saturated teal backdrop. It is the natural source of urolithin A's precursors. The camera sits at a slightly low three-quarter angle, close enough to show glossy, translucent arils. On the left half, the arils sit dull and tightly packed. On the right, a few arils hold a faint electric green glow, as if lit from within, hinting at a selective response in one place and not another. Behind the fruit, a thin copper wire runs across the frame and is unbroken on one side and fraying on the other, standing for arteries versus brain vessels. Soft, directional studio light from the upper left casts crisp shadows. Mood: curious, restrained, quietly hopeful. No text anywhere.

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Urolithin A 四周未改善动脉，但大脑有响应

BY NOVA CHEN · 2026年10月26日

一项针对 50 名年龄在 40–64 岁、患有肥胖的成年人的双盲试验发现，每日 1,000 mg 的 Urolithin A 连续四周未能提升血流介导扩张（FMD），这也是本研究的主要终点。外周微血管指标同样没有变化。然而，在认知任务期间，Urolithin A 组的大脑血流动力学响应显著高于安慰剂组，尽管任务表现并未提升。由于脑部结果来源于一次短期且样本量有限的次要分析，它更像是一个研究线索而非最终结论。下面我们将看看数据到底显示了什么、未显示什么，以及对考虑使用该补充剂的人意味着什么。